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Discerning Infection from Inflammation: a New PET/CT Technique

Antimicrobial peptide PET/CT imaging with gallium-68 appears to break through previous roadblocks in differentiating infections and sterile inflammatory processes, according to a study published in the Journal of Nuclear Medicine. Scientists evaluated a molecular imaging tracer combining the Gallium-68 radiolabeled antimicrobial peptide UBI29-41 with 1,4,7-triazacy-clononane-triacetic acid (NOTA) with preclinical PET/CT to determine if the tracer could tell the difference between muscular Staphylococcusaureus infections and inflammation. Results showed that the tracer highlighted areas of bacterial infection but was only weakly localized in areas of sterile inflammation.

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